*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LV2510000
CHEMICAL NAME           : Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,
                          5,8,8a,9-tetrahydro-9-hydroxy-
                          5-(3,4,5-trimethoxyphenyl)-,
                          (5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-
CAS REGISTRY NUMBER     : 477-47-4
OTHER CAS REGISTRY NOS. : 17434-18-3
BEILSTEIN REFERENCE NO. : 0099161
REFERENCE               : 5-19-10-00665 (Beilstein Handbook Reference)
LAST UPDATED            : 199801
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H22-O8
MOLECULAR WEIGHT        : 414.44
WISWESSER LINE NOTATION : T E5 C665 FVO NO PO OHTT&&J DR CO1 DO1 EO1& JQ
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Picropodophyllin
   * Picropodophyllotoxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 77,269,1951

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.1 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,212,1971

 
                            *** END OF RECORD ***