*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LV2520000
CHEMICAL NAME           : Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,
                          5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-
                          trimethoxyphenyl)-,
                          (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-
CAS REGISTRY NUMBER     : 4375-07-9
BEILSTEIN REFERENCE NO. : 0099162
REFERENCE               : 5-19-10-00665 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C22-H22-O8
MOLECULAR WEIGHT        : 414.44
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Epipodophyllotoxin
   * Etopside
   * VP16
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 135 mg/kg
SEX/DURATION            : female 25 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year:
   41(Suppl),91S,1984
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 5 umol/L
REFERENCE :
   JNPRDF Journal of Natural Products.  (Spahr & Glenn Co., 225 E. Spring St.,
   Columbus, OH 43215) V.42-    1979-  Volume(issue)/page/year: 52,606,1989
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 800 nmol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 15,5443,1976
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 5 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 15,5443,1976
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 40 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,512,1988
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,512,1988

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5374
       No. of Facilities: 17 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 214 (estimated)
       No. of Female Employees: 214 (estimated)

 
                            *** END OF RECORD ***