*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LY4260000
CHEMICAL NAME           : Germacra-1(10),4,11(13)-trien-12-oic acid,
                          6-beta,8-alpha-dihydroxy-, 12,6-lactone,
                          4-hydroxy-2-(hydroxymethyl)crotonate
CAS REGISTRY NUMBER     : 6856-01-5
LAST UPDATED            : 199603
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H26-O6
MOLECULAR WEIGHT        : 362.46
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Eupatoriopicrin
   * Eupatoriopicrine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   PLMEAA Planta Medica.  (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
   1, Fed. Rep. Ger.) V.1-    1953-  Volume(issue)/page/year: 53,318,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1150 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   30,3005,1981
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Ascites tumor
DOSE/DURATION           : 10 ug/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   38,2279,1989
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 ug/L
REFERENCE :
   APMCB4 Annales Pharmaceutic.  (Poznan, Poland)  V.3-13, 1965-78.
   Discontinued.  Volume(issue)/page/year: 13,131,1978
 
                            *** END OF RECORD ***