*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LY9533500
CHEMICAL NAME           : Ginseng leaves-saponins
SUBSTANCE DEFINITION :
   Purified from crude saponins of ginseng leaves
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-
LAST UPDATED            : 199506
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * GF-DS-II
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 26,209,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 306 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 23,43,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 26,209,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 26,209,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 505 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 26,209,1982
 
                            *** END OF RECORD ***