*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ4315000
CHEMICAL NAME           : Glucitol, 1-deoxy-1-(methylamino)-,
                          3,5-diacetamido-2,4,6-triiodobenzoate (salt), D-
CAS REGISTRY NUMBER     : 131-49-7
OTHER CAS REGISTRY NOS. : 69426-25-1
LAST UPDATED            : 199710
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C11-H9-I3-N2-O4.C7-H17-N-O5
MOLECULAR WEIGHT        : 809.17
WISWESSER LINE NOTATION : 1VMR BI DI FI CVQ EMV1 &Q1YQYQYQYQ1M1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Amidotrizoate meglumine
   * Angiografin
   * Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, compd. with  
   1-deoxy-1-(methylamino)-D-glucitol
   * Cardiografin
   * Diatrizoate meglumine
   * Diatrizoate methylglucamine
   * Gastrografin
   * D-Glucitol, 1-deoxy-1-(methylamino)-,  
   3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
   * Hypaque 13.4
   * Hypaque 60
   * Hypaque M 30
   * Hypaque meglumine
   * Meglumine amidotrizoate
   * Meglumine diatrizoate
   * Methylglucamine diatrizoate
   * Renograffin M-76
   * Renografin
   * RENO M 60
   * Reno-M-Dip
   * Renurix
   * Unipaque
   * Urovist
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in both tubules and glomeruli
   Kidney, Ureter, Bladder - interstitial nephritis
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,392,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14565 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAJRDX AJR, American Journal of Roentgenology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.126-    1976-
   Volume(issue)/page/year: 142,619,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44504 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AAJRDX AJR, American Journal of Roentgenology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.126-    1976-
   Volume(issue)/page/year: 142,619,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 26,921,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,32,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 26,595,1971

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81430
       No. of Facilities: 86 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1252 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81430
       No. of Facilities: 1221 (estimated)
       No. of Industries: 1
       No. of Occupations: 8
       No. of Employees: 27048 (estimated)
       No. of Female Employees: 17626 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***