*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : LZ4366500 CHEMICAL NAME : D-Glucitol, 1-deoxy-1-(methylamino)-, (R-(R*,R*))-4-((2-((3-(1H-indol-3-yl)-2-methyl-1-oxo- 2-(((tricyclo(3.3.1.1(3,7))dec-2-yloxy)carbonyl)amino )propyl)amino)-1-phen ylethyl)amino)- 4-oxobutanoate (salt) CAS REGISTRY NUMBER : 130404-91-0 LAST UPDATED : 199804 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C35-H42-N4-O6.C7-H17-N-O5 MOLECULAR WEIGHT : 810.06 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * CI988 * PD 134308 *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 2800 mg/kg/2W-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - dehydration REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 25,441,1997 *** END OF RECORD ***