*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LZ5150000
CHEMICAL NAME           : Gluconic acid, iron(2+) salt (2:1)
CAS REGISTRY NUMBER     : 299-29-6
OTHER CAS REGISTRY NOS. : 18829-42-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 17
MOLECULAR FORMULA       : C12-H22-Fe-O14
MOLECULAR WEIGHT        : 446.19
WISWESSER LINE NOTATION : Q1YQYQYQYQVO & 2-FE-
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Fergon
   * Fergon preparations
   * Ferlucon
   * Ferronicum
   * Ferrous gluconate
   * Gluco-ferrum
   * Iromin
   * Iron gluconate
   * Irox (gador)
   * Nionate
   * Ray-gluciron
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 162 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   218,1179,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2237 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: UR-3490-168
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   241,296,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   241,296,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 199 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   241,296,1961
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2600 mg/kg/13W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   24,109,1960

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 4,615,1971

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 1 mg(Fe)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,138,1971

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-DENMARK:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-FINLAND:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80415
       No. of Facilities: 181 (estimated)
       No. of Industries: 2
       No. of Occupations: 12
       No. of Employees: 14676 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80415
       No. of Facilities: 454 (estimated)
       No. of Industries: 4
       No. of Occupations: 18
       No. of Employees: 10496 (estimated)
       No. of Female Employees: 3906 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***