*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA0600200
CHEMICAL NAME           : L-Glutamic acid,
                          N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)meth
                          yl)-2-propynylamino) benzoyl)-
CAS REGISTRY NUMBER     : 76849-19-9
LAST UPDATED            : 199803
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H23-N5-O6
MOLECULAR WEIGHT        : 477.52
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   *   N-(4-(((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynilamino)benz
     oyl))-L-glutamic acid
   * CB 3717
   * N(sup 10)-Propargyl-5,8-dideazafolic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4564616
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 30 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,2346,1991
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,2036,1988
 
                            *** END OF RECORD ***