*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA0601000
CHEMICAL NAME           : Glutamic acid,
                          N-(p-((2-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino)
                          benzoyl)-
CAS REGISTRY NUMBER     : 3566-25-4
BEILSTEIN REFERENCE NO. : 1096825
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H21-N7-O6
MOLECULAR WEIGHT        : 455.48
WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EQ H2MR DVMYVQ2VQ
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-Glutamic acid,  
   N-(4-(2-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)ethylamino)benzoyl)-
   * Homofolate
   * Homofolic acid
   * 9-Methylfolic acid
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12800 ug/kg
SEX/DURATION            : female 8-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,413,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NCIMAV National Cancer Institute, Monograph.  (U.S. Government Printing
   Office, Supt. of Documents, Washington, DC 20402)  No.1-    1959-
   Volume(issue)/page/year: 2,41,1960
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   14,1541,1974
 
                            *** END OF RECORD ***