*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA0602000
CHEMICAL NAME           : Glutamic acid,
                          N-(p-((1-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino)
                          benzoyl)- L-
CAS REGISTRY NUMBER     : 2179-16-0
BEILSTEIN REFERENCE NO. : 0069787
REFERENCE               : 4-26-00-03957 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H21-N7-O6
MOLECULAR WEIGHT        : 455.48
WISWESSER LINE NOTATION : T6MTJ BZ DQ F2MR DVMYVQ2VQ
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Bremfol
   * L-Glutamic acid,  
   N-(4-((1-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl)amino)benzoyl)-
   * 9-Me-PGA
   * 9-Methyl-pga
   * 9-Methyl pteroylglutamic acid
   * Ninopterin
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 1,375,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 405 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 41,52,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 41,289,1977
 
                            *** END OF RECORD ***