*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1000000
CHEMICAL NAME           : L-Glutamic acid,
                          N-(4-(((2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)me
                          thyl)methylamino) benzoyl)-
CAS REGISTRY NUMBER     : 5939-37-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H22-N8-O6
MOLECULAR WEIGHT        : 470.50
SYNONYMS/TRADE NAMES :
   * Glutamic acid,  
   N-(p-(((2,4-diamino-7-hydroxy-6-pteridinyl)methyl)methylamino)benzoyl)-
   * 7-Hydroxymethotrexate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCPHDZ Cancer Chemotherapy and Pharmacology.  (Springer-Verlag New York,
   Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1978-
   Volume(issue)/page/year: 37,415,1996
 
                            *** END OF RECORD ***