*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1050500
CHEMICAL NAME           : L-Glutamic acid,
                          N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl
                          )-, sodium salt
CAS REGISTRY NUMBER     : 31823-54-8
OTHER CAS REGISTRY NOS. : 7551-06-6
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H20-N8-O5.xNa
MOLECULAR WEIGHT        : 601.40
SYNONYMS/TRADE NAMES :
   * Aminopterin sodium
   * Sodium aminopterin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 66,351,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg/10D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 66,351,1982
 
                            *** END OF RECORD ***