*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1225010
CHEMICAL NAME           : Glutamic acid,
                          N-(p-(((2,4-diamino-7-pteridinyl)methyl)methylamino)b
                          enzoyl)-, L-
CAS REGISTRY NUMBER     : 52980-66-2
BEILSTEIN REFERENCE NO. : 4052915
LAST UPDATED            : 199612
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H22-N8-O5
MOLECULAR WEIGHT        : 454.50
WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EZ I1N1&R DVMYVQ2VQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(4-(((2,4-Diamino-7-pteridyl)methyl)-N(sup  
   10)-methylamino)benzoyl)glutamic acid
   * 7-Mtx
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 691 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,758,1974
 
                            *** END OF RECORD ***