*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MA1247500
CHEMICAL NAME           : Glutamic acid,
                          N-(p-(((2,4-diamino-6-quinazolinyl)methyl)amino)benzo
                          yl)-, L-
CAS REGISTRY NUMBER     : 18921-68-1
LAST UPDATED            : 198312
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H22-N6-O5
MOLECULAR WEIGHT        : 438.49
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CB 3702
   * Deazaaminopterin
   * Deazaminopterin
   * L-N-(p-(((2,4-Diamino-6-quinazolinyl)methyl)amino)benzoyl)glutamic acid
   * NCS 529860
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2709506
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   GWXXBX German Offenlegungsschrift Patent Document.  (U.S. Patent and
   Trademark Office, Foreign Patents, Washington, DC 20231)
   Volume(issue)/page/year: #2709506
 
                            *** END OF RECORD ***