*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MB7605000
CHEMICAL NAME           : Glycine, N-acetyl-, compd. with
                          4,4'-(diazoamino)dibenzamidine (2:1)
CAS REGISTRY NUMBER     : 908-54-3
LAST UPDATED            : 199503
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C14-H15-N7.2C4-H7-N-O3
MOLECULAR WEIGHT        : 515.60
WISWESSER LINE NOTATION : MUYZR DNUNMR DYZUM &QV1MV1 2
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Azidin
   * Azidine
   * Berenil
   * Beronal
   * Di-(4-amidinophenyl)-triazen-(N-1,3)-diaceturat
   * Di-(4-amidinophenyl)-triazine-(N-1,3)-diaceturate
   * Diaminazene aceturate
   * 4,4'-(Diamino)dibenzamide diaceturate
   * Diminazene aceturate
   * Diminazene diaceturate
   * Diminazine aceturate
   * Ganasag
   * Ganaseg
   * Glycine, N-acetyl-, compd. with  
   4,4'-(1-triazene-1,3-diyl)bis(benzenecarboximidamide) (2:1)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 663 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RVTSA9 Research in Veterinary Science.  (British Veterinary Assoc., 7
   Mansfield St., London W1M OAT, UK)  V.1-    1960-  Volume(issue)/page/year:
   10,534,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 258 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 6,674,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCFAS Bulletin de la Societe Chimique de France.  (CDR-Centrale des Revues,
   11, rue Gossin, F-92543 Montrouge Cedex, France)  V.1-    1864-
   Volume(issue)/page/year: -,376,1968
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg/5D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   PHTOEH Pharmacology and Toxicology (Copenhagen).  (Munksgaard International
   Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  V.60-    1987-
   Volume(issue)/page/year: 64,272,1989
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8 gm/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 54,55,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 450 umol/L
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   19,1575,1983
 
TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 300,165,1993
 
                            *** END OF RECORD ***