*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MB8210000
CHEMICAL NAME : Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-,
calcium trisodium salt
CAS REGISTRY NUMBER : 12111-24-9
OTHER CAS REGISTRY NOS. : 1317-31-3
17034-67-2
51681-43-7
62796-80-9
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C14-H18-N3-O10.Ca.3Na
MOLECULAR WEIGHT : 497.40
WISWESSER LINE NOTATION : OV1N1VO&2N1VO2N1VO&1VO &-NA- 3 &-CA-
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-, calcium
trisodium salt
* Ba 2797
* N,N-Bis(2-(bis(carboxymethyl)amino)ethyl)glycine calcium trisodium salt
* Calciate(3)-, (N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))-,
trisodium
* Calcium chel-330
* Calcium-dtpa
* Calcium trisodium chel 330
* Calcium trisodium diethylenetriaminepentaacetate
* Calcium trisodium DTPA
* Calcium trisodium pentetate
* Calcium trisodium salt of diethylenetriaminepentaacetic acid
* Diethylenetriamine pentaacetic acid, calcium trisodium salt
* Ditripentat
* DTPA calcium trisodium salt
* Pentacin
* Pentacine
* Pentetate trisodium calcium
* Penthamil
* Trisodium calcium diethylenetriaminepentaacetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2512 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAJRDX AJR, American Journal of Roentgenology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.126- 1976-
Volume(issue)/page/year: 142,619,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7269 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
Volume(issue)/page/year: 64,247,1989
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 659 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W.
Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:
23,908,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1790 mg/kg
SEX/DURATION : female 9-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
HOKBAQ Hoken Butsuri. Health Physics. (Nihon Hoken Butsuri Kyogikai, c/o
Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1-
1966- Volume(issue)/page/year: 18,37,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2685 mg/kg
SEX/DURATION : female 9-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
HOKBAQ Hoken Butsuri. Health Physics. (Nihon Hoken Butsuri Kyogikai, c/o
Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1-
1966- Volume(issue)/page/year: 18,37,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 3581 mg/kg
SEX/DURATION : female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 14,123,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 30 gm/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
HLTPAO Health Physics. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,780,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 3580 mg/kg
SEX/DURATION : female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
HLTPAO Health Physics. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 33,624,1977
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 4 mmol/kg
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
23,901,1974
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 20 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
23,901,1974
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
23,901,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9954
No. of Facilities: 116 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 1702 (estimated)
No. of Female Employees: 1258 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***