*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MB8469000
CHEMICAL NAME           : Glycine,
                          N,N'-((bis(2-chloroethyl)amino)phosphinylidene)di-,
                          diethyl ester
CAS REGISTRY NUMBER     : 7568-40-3
BEILSTEIN REFERENCE NO. : 2012594
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H24-Cl2-N3-O5-P
MOLECULAR WEIGHT        : 392.26
SYNONYMS/TRADE NAMES :
   * N,N'-((Bis(2-chloroethyl)amino)phosphinylidene)diglycine diethyl ester
   * Glyciphosphoramide
   * M 25
   * Z-6202
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 580 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CIHPDR Zhongguo Yixue Kexueyuan Xuebao.  Journal of the Chinese Academy of
   Medicine.  (China International Book Trading Corp., POB 2820, Beijing, Peop.
   Rep. China)  V.1-    1979-  Volume(issue)/page/year: 6,334,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CIHPDR Zhongguo Yixue Kexueyuan Xuebao.  Journal of the Chinese Academy of
   Medicine.  (China International Book Trading Corp., POB 2820, Beijing, Peop.
   Rep. China)  V.1-    1979-  Volume(issue)/page/year: 6,334,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg/10D-I
TOXIC EFFECTS :
   Endocrine - changes in thymus weight
   Blood - changes in other cell count (unspecified)
REFERENCE :
   CIHPDR Zhongguo Yixue Kexueyuan Xuebao.  Journal of the Chinese Academy of
   Medicine.  (China International Book Trading Corp., POB 2820, Beijing, Peop.
   Rep. China)  V.1-    1979-  Volume(issue)/page/year: 6,334,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 560 mg/kg/7D-I
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
   Blood - changes in platelet count
   Related to Chronic Data - death
REFERENCE :
   CIHPDR Zhongguo Yixue Kexueyuan Xuebao.  Journal of the Chinese Academy of
   Medicine.  (China International Book Trading Corp., POB 2820, Beijing, Peop.
   Rep. China)  V.1-    1979-  Volume(issue)/page/year: 6,334,1984
 
                            *** END OF RECORD ***