*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MB8480000
CHEMICAL NAME           : Glycine, N,N-bis(2-chloroethyl)-, hydrochloride
CAS REGISTRY NUMBER     : 2619-97-8
LAST UPDATED            : 199203
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H11-Cl2-N-O2.Cl-H
MOLECULAR WEIGHT        : 236.54
WISWESSER LINE NOTATION : QV1N2G2G &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N,N-Bis(beta-chloroethyl)glycine hydrochloride
   * N,N-Bis(2-chloroethyl)glycine hydrochloride
   * Glycine mustard
   * Glycine nitrogen mustard
   * NSC 17661
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 113 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 18,760,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PHBUA9 Pharmaceutical Bulletin.  (Tokyo, Japan)  V.1-5, 1953-57.  For
   publisher information, see CPBTAL.  Volume(issue)/page/year: 2,275,1954
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - leukopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
                            *** END OF RECORD ***