*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR7040000
CHEMICAL NAME           : 9-Acridanone, 10-(3-(dimethylamino)propyl)-1-nitro-,
                          hydrochloride
CAS REGISTRY NUMBER     : 24268-89-1
LAST UPDATED            : 199309
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H19-N3-O3.Cl-H
MOLECULAR WEIGHT        : 361.86
WISWESSER LINE NOTATION : T C666 BN IVJ B3N1&1 GNW &GH
SYNONYMS/TRADE NAMES :
   * 9(10H)-Acridinone, 10-(3-(dimethylamino)propyl)-1-nitro-,  
   monohydrochloride
   * C-492
   * 10-(3-(Dimethylamino)propyl)-1-nitro-9-acridanone hydrochloride
   * 1-Nitro-14-(dimethylaminopropyl)-acridone hydrochloride
   * 1-Nitro-10-(3-dimethylaminopropyl)-acridone hydrochloride
   * 1-Nitro-10-(3-dimethylaminopropyl)-acridon hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 53300 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - necrotic changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   21,775,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - necrotic changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   21,775,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17500 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   MMDPA6 Materia Medica Polona (English Edition).  (Ars Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.1-    1969-  Volume(issue)/page/year: 8,252,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - necrotic changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   21,775,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,777,1980
 
                            *** END OF RECORD ***