*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR8200000
CHEMICAL NAME           : Acridine,
                          9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-4-m
                          ethoxy-, dihydrochloride
CAS REGISTRY NUMBER     : 38915-14-9
LAST UPDATED            : 199603
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H26-Cl-N3-O.2Cl-H
MOLECULAR WEIGHT        : 444.87
WISWESSER LINE NOTATION : T C666 BNJ DO1 IM3N2&2G &GH 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 9-(3-(Ethyl-2-chloroethyl)aminopropylamino)-4-methoxyacridine  
   dihydrochloride
   * ICR 377
   * 4-Methoxy-9-(3-(ethyl-2-chloroethyl)aminopropylamino)acridine  
   dihydrochloride
   * 1,3-Propanediamine,  
   N-(2-chloroethyl)-N-ethyl-N'-(4-methoxy-9-acridinyl)-, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,185,1984
 
                            *** END OF RECORD ***