*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR9532500
CHEMICAL NAME           : Acridine, 1,2,3,4-tetrahydro-9-amino-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 1684-40-8
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C13-H14-N2.Cl-H
MOLECULAR WEIGHT        : 234.75
WISWESSER LINE NOTATION : T C666 BN&&TJ IZ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 9-Acridinamine, 1,2,3,4-tetrahydro-, monohydrochloride
   * Acridine, 9-amino-1,2,3,4-tetrahydro-, hydrochloride
   * CI 970
   * Hydroaminacrine
   * Romotal
   * Tacrine hydrochloride
   * Tacrin hydrochloride
   * Tenakrin
   * Tetrahydroaminacrin
   * 1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride
   * T.H.A.
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 10,638,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#07602
 
                            *** END OF RECORD ***