*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AR9660000
CHEMICAL NAME : Acridinium, 3,6-diamino-10-methyl-, chloride mixed
with 3,6-acridinediamine
CAS REGISTRY NUMBER : 8048-52-0
OTHER CAS REGISTRY NOS. : 53307-10-1
51555-26-1
LAST UPDATED : 199706
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C14-H14-N3.Cl.C13-H11-N3
MOLECULAR WEIGHT : 469.03
WISWESSER LINE NOTATION : T C666 BKJ B1 EZ MZ &G &T C666 BNJ EZ MZ
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Angiflan
* Assiflavine
* Bialflavina
* Bioacridin
* Bovoflavin
* Buroflavin
* Choliflavin
* Diacrid
* 3,6-Diaminoacridine mixture with 3,6-diamino-10-methylacridinium chloride
* 3,6-Diamino-10-methylacridinium chloride mixture with 3,6-acridinediamine
* 2,8-Diamino-10-methylacridinium chloride mixture with 2,8-diaminoacridine
* Flavacridinum hydrochloricum
* Flavine
* Flavinetten
* Flavioform
* Flavipin
* Flavisept
* Glyco-flavine
* Gonacin
* Gonacrine
* Isravin
* Mediflavin
* Panflavin
* Pantonsiletten
* Tolivalin
* Trachosept
* Tripla-etilo
* Vetaflavin
* Xanthacridinum
* Zoriflavin
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 160 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
SEMEAS Semana Medica. (Sociedad Argentina de Gastroenterologica, Santa Fe
1171, Buenos Aires, Argentina) V.1- 1894- Volume(issue)/page/year:
159,778,1952
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 40 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 25 umol/L
REFERENCE :
JSPMAW Journal of Supramolecular Structure. (Alan R. Liss, Inc., 41 E. 11th
St., New York, NY 10003) V.1- 1972- Volume(issue)/page/year: 1,449,1973
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 10 mg/L
REFERENCE :
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1960- Volume(issue)/page/year: 7,207,1966
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 5 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Mammary gland
DOSE/DURATION : 100 nmol/L
REFERENCE :
JOBIAO Journal of Biochemistry (Tokyo). (Japanese Biochemical Soc., c/o
Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1-
1922- Volume(issue)/page/year: 84,145,1978
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.)
V.1-104, 1875-1979. Volume(issue)/page/year: 92,2315,1967
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,291,1984
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 25 mg/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,55,1981
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,31,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,31,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1531
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 40 (estimated)
No. of Female Employees: 10 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation
EPA GENETOX PROGRAM 1988, Positive: In vitro mammalian nonhuman micronucleus
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte;
Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; S cerevisiae
gene conversion
*** END OF RECORD ***