*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AS0300000
CHEMICAL NAME           : Acriflavine
CAS REGISTRY NUMBER     : 65589-70-0
LAST UPDATED            : 199603
DATA ITEMS CITED        : 7
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Flavacridine
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg/21D-I
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in spleen
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 16,1038,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 131,193,1984
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 6 mg/L/2H (Continuous)
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 14,61,1968
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 mg/L/2D
REFERENCE :
   JULRA7 Journal of Ultrastructure Research.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1975-  Volume(issue)/page/year:
   25,37,1968
 
TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 138,169,1984
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 pph
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 121,199,1983
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 umol/L
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 37,334,1969
 
                            *** END OF RECORD ***