*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AS7000000
CHEMICAL NAME : Acrylic acid, 2-cyano-, methyl ester
CAS REGISTRY NUMBER : 137-05-3
BEILSTEIN REFERENCE NO. : 1751282
REFERENCE : 4-02-00-02226 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 28
MOLECULAR FORMULA : C5-H5-N-O2
MOLECULAR WEIGHT : 111.11
WISWESSER LINE NOTATION : 1UYCN&VO1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Adhere
* Coapt
* alpha-Cyanoacrylic acid methyl ester
* 2-Cyanoacrylic acid, methyl ester
* Cyanolit
* Eastman 910
* Eastman 910 adhesive
* Eastman 910 monomer
* Mecrilat
* Mecrylate
* Methyl cyanoacrylate
* Methyl alpha-cyanoacrylate
* Methyl 2-cyanoacrylate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human
DOSE/DURATION : 4 ppm
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
29,558,1968
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,965,1991
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 101 ppm/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,965,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >10959 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,965,1991
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Primate - monkey
DOSE : 100 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year:
39(Suppl),441,1983
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 300 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,97,1987
*** REVIEWS ***
ACGIH TLV-STEL 18 mg/m3 (4 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 9.1 mg/m3 (2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2 ppm (8 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,162,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 2 ppm (8 mg/m3) JAN 1993
OEL-BELGIUM:TWA 2 ppm (9.1 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993
OEL-DENMARK:TWA 2 ppm (8 mg/m3) JAN 1993
OEL-FINLAND:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993
OEL-GERMANY:TWA 2 ppm (8 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (8 mg/m3) JAN 1993
OEL-SWEDEN:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL 2-CYANOACRYLATE-air:10H TWA 2 ppm;STEL 4 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4755
No. of Facilities: 895 (estimated)
No. of Industries: 25
No. of Occupations: 25
No. of Employees: 18406 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4755
No. of Facilities: 1434 (estimated)
No. of Industries: 46
No. of Occupations: 51
No. of Employees: 51367 (estimated)
No. of Female Employees: 22918 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
OSHA ANALYTICAL METHOD #ID-55
*** END OF RECORD ***