*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AU1400000
CHEMICAL NAME : Actinomycin C
CAS REGISTRY NUMBER : 8052-16-2
LAST UPDATED : 199604
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C62-H89-N11-O17
MOLECULAR WEIGHT : 1260.62
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Actinochrysin
* Cactinomycin
* Mixture of dactinomycin (10%), actinomycin C2 (45%), and actinomycin C3
(45%)
* HBF 386
* NSC-18 268
* Sanamicia
* Sanamycin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,1467,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
Volume(issue)/page/year: 52,76,1975
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research
Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information,
see TAKHAA. Volume(issue)/page/year: 14,60,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1110 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 230,559,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),53,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 350 ug/kg
SEX/DURATION : female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 350 ug/kg
SEX/DURATION : female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City
Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher
information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
** MUTATION DATA **
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 120 mg/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH,
Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-
Volume(issue)/page/year: 8,139,1968
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,197,1986
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 475 ug/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress
in Research and Clinical Application, 7th Proceedings of the International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3 vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 47 ug/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress
in Research and Clinical Application, 7th Proceedings of the International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3 vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 475 ug/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress
in Research and Clinical Application, 7th Proceedings of the International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3 vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 47 ug/L
REFERENCE :
26QZAP "Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress
in Research and Clinical Application, 7th Proceedings of the International
Congress of Chemotherapy, Prague, 1971," Hejzlar, M., et al., eds., 3 vols.,
Prague, Czechoslovakia, Univ. Press, 1972 Volume(issue)/page/year:
2,395,1972
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 1 ug/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 22,105,1975
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 1 ug/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 22,105,1975
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Cells - not otherwise
specified
DOSE/DURATION : 500 ug/L
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental
Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
Volume(issue)/page/year: 12,280,1970
*** REVIEWS ***
IARC Cancer Review:Animal NO EVIDENCE
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,29,1976
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For
publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965
*** END OF RECORD ***