*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU4717000
CHEMICAL NAME           : 1-Adamantanemethylamine, alpha-methyl-, hydrochloride
CAS REGISTRY NUMBER     : 1501-84-4
LAST UPDATED            : 199803
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H21-N.Cl-H
MOLECULAR WEIGHT        : 215.80
WISWESSER LINE NOTATION : L66 B6/B-H/DI A B- C 1B ITJ BYZ1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Adamantane, 1-(1-aminoethyl)-, hydrochloride
   * 1-(1-Aminoethyl)adamantane hydrochloride
   * EXP 126
   * JP 61
   * Meradan
   * Meradane
   * alpha-Methyl-1-adamantanemethylamine hydrochloride
   * alpha-Methyltricyclo(3.3.1.1(sup 3,7))decane-1-methanamine hydrochloride
   * Remantadin
   * Rimantadine hydrochloride
   * Tricyclo(3.3.1.1(sup 3,7))decane-1-methanamine, alpha-methyl-,  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 28(9),23,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 11,798,1977
 
                            *** END OF RECORD ***