*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR7350000
CHEMICAL NAME           : Acridine, 9-amino-, hydrochloride
CAS REGISTRY NUMBER     : 134-50-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C13-H10-N2.Cl-H
MOLECULAR WEIGHT        : 230.71
WISWESSER LINE NOTATION : T C666 BNJ IZ &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acramine Yellow
   * 9-Acridinamine, monohydrochloride
   * Aminacrine hydrochloride
   * 5-Aminoacridine hydrochloride
   * 9-Aminoacridine hydrochloride
   * 9-Aminoacridine monohydrochloride
   * Monacrin hydrochloride
   * NSC-7571
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,7,1969
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 16,6240,1982
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 17,70,1983
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 60 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,1,1982
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 60 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,1,1982
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 600 ug/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 10 pph
REFERENCE :
   BIPMAA Biopolymers.  (John Wiley & Sons, Inc., 605 Third Ave., New York, NY
   10158)  V.1-    1963-  Volume(issue)/page/year: 11,2537,1972

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   13,747,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 04770
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 04770
       No. of Facilities: 9 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 166 (estimated)
       No. of Female Employees: 105 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***