*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AU7357560 CHEMICAL NAME : Adenosine, 2-chloro-2'-deoxy- CAS REGISTRY NUMBER : 4291-63-8 BEILSTEIN REFERENCE NO. : 0624220 LAST UPDATED : 199807 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C10-H12-Cl-N5-O3 MOLECULAR WEIGHT : 285.72 COMPOUND DESCRIPTOR : Drug Mutagen Human SYNONYMS/TRADE NAMES : * 2-Chloro-2'-deoxyadenosine * Cladribine * Leustatin * RWJ 26251 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 700 ug/kg/7D-C TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : AJHEDD American Journal of Hematology. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1976- Volume(issue)/page/year: 53,209,1996 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : LELYEA Leukemia and Lymphoma. (Harwood Academic Publishers GmbH c/o STBS Ltd., POB 90 Reading, Berks, RG1 8JL, UK) V.1- 1989- Volume(issue)/page/year: 5,1,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg/5D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : LELYEA Leukemia and Lymphoma. (Harwood Academic Publishers GmbH c/o STBS Ltd., POB 90 Reading, Berks, RG1 8JL, UK) V.1- 1989- Volume(issue)/page/year: 5,1,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 7 mg/kg/7D-C TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Blood - granulocytopenia REFERENCE : LELYEA Leukemia and Lymphoma. (Harwood Academic Publishers GmbH c/o STBS Ltd., POB 90 Reading, Berks, RG1 8JL, UK) V.1- 1989- Volume(issue)/page/year: 5,1,1991 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 16 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,2362,1986 *** END OF RECORD ***