*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU7357560
CHEMICAL NAME           : Adenosine, 2-chloro-2'-deoxy-
CAS REGISTRY NUMBER     : 4291-63-8
BEILSTEIN REFERENCE NO. : 0624220
LAST UPDATED            : 199807
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H12-Cl-N5-O3
MOLECULAR WEIGHT        : 285.72
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 2-Chloro-2'-deoxyadenosine
   * Cladribine
   * Leustatin
   * RWJ 26251
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 700 ug/kg/7D-C
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJHEDD American Journal of Hematology.  (John Wiley & Sons, 605 Third
   Avenue, New York, NY 10158) V.1-    1976-  Volume(issue)/page/year:
   53,209,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LELYEA Leukemia and Lymphoma.  (Harwood Academic Publishers GmbH c/o STBS
   Ltd., POB 90 Reading, Berks, RG1 8JL, UK)  V.1-   1989-
   Volume(issue)/page/year: 5,1,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg/5D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   LELYEA Leukemia and Lymphoma.  (Harwood Academic Publishers GmbH c/o STBS
   Ltd., POB 90 Reading, Berks, RG1 8JL, UK)  V.1-   1989-
   Volume(issue)/page/year: 5,1,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 7 mg/kg/7D-C
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - granulocytopenia
REFERENCE :
   LELYEA Leukemia and Lymphoma.  (Harwood Academic Publishers GmbH c/o STBS
   Ltd., POB 90 Reading, Berks, RG1 8JL, UK)  V.1-   1989-
   Volume(issue)/page/year: 5,1,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 16 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,2362,1986
 
                            *** END OF RECORD ***