*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MC0555000
CHEMICAL NAME           : Glycine, N-formyl-N-hydroxy-, sodium salt
CAS REGISTRY NUMBER     : 2618-22-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C3-H4-N-O4.Na
MOLECULAR WEIGHT        : 141.07
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * N-Formylhydroxyaminoessigsaeure-natrium
   * Hadacidin sodium
   * Sodium hadacidin
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1176 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 39,203,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1764 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 39,203,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1764 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 39,203,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 4 gm/L/2D
REFERENCE :
   ECEBDI Experimental Cell Biology.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.44-    1976-  Volume(issue)/page/year: 46,152,1978
 
                            *** END OF RECORD ***