*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MC0840000
CHEMICAL NAME           : Glycine, 2-phenyl-, isopentyl ester, hydrochloride,
                          DL-
CAS REGISTRY NUMBER     : 31031-74-0
LAST UPDATED            : 199012
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H19-N-O2.Cl-H
MOLECULAR WEIGHT        : 257.79
WISWESSER LINE NOTATION : ZYR&VO2Y1&1 &GH -DL
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Aklonin
   * Aklonine
   * (+-)-alpha-Aminobenzeneacetic acid 3-methylbutyl ester hydrochloride
   * Benzeneacetic acid, alpha-amino-, 3-methylbutyl ester, hydrochloride,  
   (+-)-
   * Isoamyl phenylaminoacetate hydrochloride
   * Isopentyl 2-phenylglycinate hydrochloride
   * 3-Methylbutyl alpha-aminobenzeneacetate hydrochloride (+-)-
   * Phenamacide hydrochloride
   * Phenylaminoacetic acid isoamyl ester hydrochloride
   * 2-Phenylglycine isopentyl ester hydrochloride
   * D,L-2-Phenylglycinisoamylesterhydrochlorid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   33,749,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 415 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   30,765,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   33,749,1978
 
                            *** END OF RECORD ***