*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MC1075000
CHEMICAL NAME : Glycine, N-(phosphonomethyl)-
CAS REGISTRY NUMBER : 1071-83-6
BEILSTEIN REFERENCE NO. : 2045054
LAST UPDATED : 199712
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C3-H8-N-O5-P
MOLECULAR WEIGHT : 169.09
WISWESSER LINE NOTATION : QV1M1PQQO
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Glyphosate
* MON 0573
* MON 2139
* N-(Phosphonomethyl)glycine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2143 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - fibrosis (interstitial)
Lungs, Thorax, or Respiration - fibrosing alveolitis
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
29,91,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1214 mg/kg
TOXIC EFFECTS :
Cardiac - change in rate
Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road,
Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
Volume(issue)/page/year: 10,103,1991
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
29,91,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4873 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,319,1978
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >12200 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A222,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 235 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1000(Sp Iss
1),148,198
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1568 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,319,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1000(Sp Iss
1),148,198
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400
Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-
Volume(issue)/page/year: 7,6,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 7940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A222,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : >4640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,459,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 153 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3135
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22500 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
HCKHDV Huanjing Kexue. Environmental Sciences. (China International Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1976- Adopted vol.
no. with Vol. 1, 1980. Volume(issue)/page/year: 5(2),52,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 435 gm/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3135
*** STATUS IN U.S. ***
On EPA IRIS database
NTP Toxicity studies, RPT# TOX-16, October 1997
*** END OF RECORD ***