*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MD5431000
CHEMICAL NAME           : Gold, chloro(triethylphosphine)-
CAS REGISTRY NUMBER     : 15529-90-5
LAST UPDATED            : 199112
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C6-H15-Au-Cl-P
MOLECULAR WEIGHT        : 350.60
WISWESSER LINE NOTATION : G-AU-UP3&3&3
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Chloro(triethylphosphine)gold
   * SK&F 36914
   * Triethylphosphineaurous chloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),1,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),1,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 92560 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),97,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 46280 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),97,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 37500 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,3243,1985
 
                            *** END OF RECORD ***