*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MD5435000
CHEMICAL NAME : Gold, ((1,2-dicarboxyethyl)thio)-, disodium salt
CAS REGISTRY NUMBER : 12244-57-4
OTHER CAS REGISTRY NOS. : 3504-43-6
16905-00-3
18911-13-2
LAST UPDATED : 199504
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C4-H3-Au-O4-S.2Na
MOLECULAR WEIGHT : 390.08
WISWESSER LINE NOTATION : OVYVO&1S-AU- &-NA- 2
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aurothiomaleate sodium
* AuTM
* Butanedioic acid, mercapto-, monogold(1+) sodium salt
* Chrysothios
* ((1,2-Dicarboxyethyl)thio)gold disodium salt
* (Dihydrogen mercaptosuccinato)gold disodium salt
* Disodium aurothiomalate
* Gold sodium thiomalate
* Kidon
* (Mercaptobutanedioato(1-))gold disodium salt
* Miochrysin
* Myochrysine
* Myocrisin
* Sodium aurithiomalate
* Sodium aurothiomalate
* Succinic acid, mercapto-, gold sodium salt
* Tauredon
* Taure(o)don
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5500 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from peripheral motor nerve
Kidney, Ureter, Bladder - renal function tests depressed
Blood - thrombocytopenia
REFERENCE :
ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St.,
NW, Atlanta, GA 30309) V.1- 1958- Volume(issue)/page/year: 19,936,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 182 ug/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,1294,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2700 ug/kg/4W-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 11,235,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 20 mg/kg/1Y
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - aggression
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 96,133,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5 mg/kg/13W
TOXIC EFFECTS :
Blood - hemorrhage
Blood - thrombocytopenia
Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
133,754,1947
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 600 ug/kg/1W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis (interstitial)
Liver - jaundice, cholestatic
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JRSMD9 Journal of the Royal Society of Medicine. (Oxford Univ. Press,
Walton St., Oxford OX2 6DP, UK) V.71- 1978- Volume(issue)/page/year:
77,960,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 3366 ug/kg/2W
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - muscle weakness
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
55802) V.1- 1951- Volume(issue)/page/year: 20,455,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 12500 ug/kg/7W-I
TOXIC EFFECTS :
Brain and Coverings - encephalitis
Peripheral Nerve and Sensation - fasciculations
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 11,233,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 7857 ug/kg/11W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
Immunological Including Allergic - uncharacterized
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
286,1547,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - child
DOSE/DURATION : 11900 ug/kg/18W-I
TOXIC EFFECTS :
Biochemical - Metabolism (Intermediary) - other
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 13,224,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human
DOSE/DURATION : 9750 ug/kg/23W-I
TOXIC EFFECTS :
Blood - changes in cell count (unspecified)
Blood - aplastic anemia
Blood - other changes
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,1266,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 12 mg/kg
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 13,225,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1600 ug/kg/3W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Blood - agranulocytosis
REFERENCE :
ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of
Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
V.1- 1971- Volume(issue)/page/year: 16,72,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 7 mg/kg/7W-I
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 12,180,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 7857 ug/kg/11W-I
TOXIC EFFECTS :
Immunological Including Allergic - uncharacterized
REFERENCE :
BJRHDF British Journal of Rheumatology. (Bailliere Tindall, 33 The Avenue,
Eastborn BN21 3UN, UK) Volume(issue)/page/year: 24,367,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 303 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,208,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,208,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 49,121,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 930 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,208,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 855 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,208,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VTPHAK Veterinary Pathology. (Waverly Press, Inc., POB 64025, Baltimore, MD
21264) V.8- 1971- Volume(issue)/page/year: 15(Suppl 5),1,1978
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 75 mg/kg
SEX/DURATION : female 4-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 214,250,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 75 mg/kg
SEX/DURATION : female 13-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 214,250,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 250 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
VTPHAK Veterinary Pathology. (Waverly Press, Inc., POB 64025, Baltimore, MD
21264) V.8- 1971- Volume(issue)/page/year: 15(Suppl 5),89,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 100 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
58,149,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 900 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
VTPHAK Veterinary Pathology. (Waverly Press, Inc., POB 64025, Baltimore, MD
21264) V.8- 1971- Volume(issue)/page/year: 15(Suppl 5),89,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 257 mg/kg
SEX/DURATION : female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
VTPHAK Veterinary Pathology. (Waverly Press, Inc., POB 64025, Baltimore, MD
21264) V.8- 1971- Volume(issue)/page/year: 15(Suppl 5),97,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc.,
1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year:
13(1),209,1974
TOXICOLOGY REVIEW
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher
information, see PHTHDT. Volume(issue)/page/year: 1,119,1976
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6050
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 731 (estimated)
No. of Female Employees: 366 (estimated)
*** END OF RECORD ***