*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MD6300000
CHEMICAL NAME           : Gold sodium thiosulfate, dihydrate
CAS REGISTRY NUMBER     : 10210-36-3
LAST UPDATED            : 199203
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : O6-S4.Au.3Na.2H2-O
MOLECULAR WEIGHT        : 503.23
WISWESSER LINE NOTATION :  NA3 AU S2-O3*2 &QH 2
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Auricidine
   * Aurocidin
   * Aurolin
   * Auropex
   * Auropin
   * Aurosan
   * Aurothion
   * Crisalbine
   * Novacrysin
   * Sanochrysine
   * Sodium aurothiosulphate dihydrate
   * Solfocrisol
   * Thiochrysine
   * Thiosulfuric acid, gold(1+) sodium salt(2:1:3), dihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 400 ug/kg/1W
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, irritative (after systemic exposure)
   Blood - granulocytopenia
   Blood - thrombocytopenia
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   37,323,1952
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 49,121,1942
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 12,274,1985
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin.  (Berlin, Fed.
   Rep. Ger.)  V.1-139, 1913-65.  For publisher information, see REXMAS.
   Volume(issue)/page/year: 57,77,1927
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EMSUA8 Experimental Medicine and Surgery.  (Brooklyn, NY)  V.1-29, 1943-71.
   Suspended.  Volume(issue)/page/year: 3,146,1945

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   MDCHAG Medicinal Chemistry: A Series of Monographs.  (Academic Press, Inc.,
   1 E. First St., Duluth, MN 55802)  V.1-    1963-  Volume(issue)/page/year:
   13(1),209,1974

   TOXICOLOGY REVIEW
   PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
   Metabolic Inhibitors. (Oxford, UK)  V.1-2, 1976-78.  For publisher
   information, see PHTHDT.  Volume(issue)/page/year: 1,119,1976

 
                            *** END OF RECORD ***