*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MD6475000
CHEMICAL NAME : Gold, (1-thio-D-glucopyranosato)-
CAS REGISTRY NUMBER : 12192-57-3
LAST UPDATED : 199606
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C6-H11-O5-S.Au
MOLECULAR WEIGHT : 392.20
WISWESSER LINE NOTATION : T6OTJ BS-AU-H CQ DQ EQ F1Q
COMPOUND DESCRIPTOR : Tumorigen
Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aureotan
* Auromyose
* Aurotan
* 1-Aurothio-D-glucopyranose
* Aurothioglucose
* Aurumine
* Authron
* Brenol
* (D-Glucopyranosylthio)gold
* (1-D-Glucosylthio)gold
* Glysanol B
* Gold, (D-glucopyranosylthio)-
* Gold thioglucose
* GTG
* Oronol
* Romosol
* SKF 10056
* Solganal
* Solganal B
* (1-Thio-D-glucopyranosato)gold
* 1-Thio-D-glucopyranose, gold complex
* 1-Thio-glucopyranose, monogold(1+) salt
* 1-Thio-D-glucopyranose, monogold(1+) salt
* Thioglucose d'or
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5500 ug/kg/10W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 88,644,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2600 ug/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Liver - other changes
REFERENCE :
ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St.,
NW, Atlanta, GA 30309) V.1- 1958- Volume(issue)/page/year: 27,230,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 3357 ug/kg/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 12,619,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2700 ug/kg/4W-I
TOXIC EFFECTS :
Liver - jaundice, cholestatic
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 11,843,1984
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SAVEAB Sammlung von Vergiftungsfaellen. (Berlin, Germany) V.1-13, 1930-44;
V.14, 1952-54. For publisher information, see ARTODN.
Volume(issue)/page/year: 10,101A,1939
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - effect on inflammation or
mediation of inflammation
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 70,498,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71.
Suspended. Volume(issue)/page/year: 3,146,1945
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St.,
Champaign, IL 61820) V.1- 1921- Volume(issue)/page/year: 52,926,1973
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Spinal Cord - other degenerative changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
35,223,1976
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 3,37,1959
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France)
V.1-14, 1956-69. For publisher information, see BIMDB3.
Volume(issue)/page/year: 13,40,1968
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France)
V.1-14, 1956-69. For publisher information, see BIMDB3.
Volume(issue)/page/year: 11,828,1966
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 400 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 124,1190,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE : 800 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
78,845,1966
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,39,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 13,39,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc.,
1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year:
13(1),209,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1852
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 7622 (estimated)
No. of Female Employees: 7177 (estimated)
*** END OF RECORD ***