*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MD9100000
CHEMICAL NAME           : Granaticin
CAS REGISTRY NUMBER     : 19879-06-2
LAST UPDATED            : 199512
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C22-H20-O10
MOLECULAR WEIGHT        : 444.42
WISWESSER LINE NOTATION : T F5 E6 C6666/RW 2AQ W DV GOV KO NV TOTT&&TTJ BQ L1
                          PQ RQ S1 WQ
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic WR 141
   * Granaticin A
   * Granatomycin C
   * Litmomycin
   * WR 141
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   17,63,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,135,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEXXA8 German (East) Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #147115
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
   Tokyo, Univ. of Tokyo Press, 1967  Volume(issue)/page/year: -,823,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 600 nmol/L
REFERENCE :
   ZBPHA6 Zentralblatt fuer Bakteriologie, Parasitenkunde,
   Infektionskrankheiten und Hygiene, Abteilung I: Medizinisch-Hygienische
   Bakteriologie, Virusforschung und Parasitologie, Originale. (Stuttgart, Fed.
   Rep. Ger.)  V.31-216, 1902-71.  For publisher information, see ZMMPAO.
   Volume(issue)/page/year: 212,259,1969
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 600 nmol/L
REFERENCE :
   ZBPHA6 Zentralblatt fuer Bakteriologie, Parasitenkunde,
   Infektionskrankheiten und Hygiene, Abteilung I: Medizinisch-Hygienische
   Bakteriologie, Virusforschung und Parasitologie, Originale. (Stuttgart, Fed.
   Rep. Ger.)  V.31-216, 1902-71.  For publisher information, see ZMMPAO.
   Volume(issue)/page/year: 212,259,1969
 
                            *** END OF RECORD ***