*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ME8510500
CHEMICAL NAME           : Guanidine, (1,4-benzodioxan-6-ylmethyl)-, sulfate
                          (2:1)
CAS REGISTRY NUMBER     : 17471-82-8
LAST UPDATED            : 199109
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H13-N3-O2.1/2H2-O4-S
MOLECULAR WEIGHT        : 256.26
WISWESSER LINE NOTATION : T66 BO EOT&J H1MYZUM 2 &..H2.S-O4
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(1,4-Benzodioxan-6-ylmethyl)guanidine sulfate (2:1)
   * Guabenxane
   * Guanidine, ((2,3-dihydro-1,4-benzodioxin-6-yl)methyl)-, sulfate (2:1)
   * Guanidino-6-methyl-1,4-benzodioxane
   * 6-Guanidinomethyl 1,4-benzodioxane sulfate
   * Guanidino methyl-6 benzodioxanne-1,4
   * Hemisulfate de guanidino methyl-6 benzodioxanne-1,4
   * LM 433
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2564 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 12,241,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 243 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 12,241,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 535 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 12,241,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 12,241,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 23,1221,1968
 
                            *** END OF RECORD ***