*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF0035100
CHEMICAL NAME           : Guanidine,
                          N-cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl
                          )methyl)thio)ethyl)-, monohydrochloride
CAS REGISTRY NUMBER     : 70059-30-2
LAST UPDATED            : 199504
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H16-N6-S.Cl-H
MOLECULAR WEIGHT        : 288.84
COMPOUND DESCRIPTOR     : Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Cimetex
   * Cimetidine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 12 mg/kg/6H-I
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 75,1283,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 500 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,833,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3086
       No. of Facilities: 485 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 17435 (estimated)
       No. of Female Employees: 14362 (estimated)

 
                            *** END OF RECORD ***