*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF2000000
CHEMICAL NAME           : Guanidine,
                          2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 537-05-3
LAST UPDATED            : 199012
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C23-H25-N3-O3.Cl-H
MOLECULAR WEIGHT        : 427.97
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acoin
   * Acoine
   * Acoin hydrochloride
   * Akoin hydrochlorid
   * N,N'-Bis(4-methoxyphenyl)-N''-(4-ethoxyphenyl)guanidine hydrochloride
   * alpha,gamma-Di-p-anisyl-beta-(ethoxyphenyl)guanidine hydrochloride
   * Dianisyl-monophenethylguanidine hydrochloride
   * Diparaanisyl-monophenethyl-guanidin-hydrochlorid
   * 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride
   * Guanicaine
   * Guanidine, 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)-, hydrochloride
   * Phenodianisyl
   * Phenodianisyl hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G.,
   Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 
   Volume(issue)/page/year: -,-,1933
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische
   Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M.,
   Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger.
   Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1291,1935
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065)  10th ed. 1983.
   For publisher information, see 85KYAH.  Volume(issue)/page/year:
   10,1043,1983
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1291,1935
 
                            *** END OF RECORD ***