*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF3150000
CHEMICAL NAME           : Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-,
                          sulfate (1:1)
CAS REGISTRY NUMBER     : 645-43-2
LAST UPDATED            : 198809
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H22-N4.H2-O4-S
MOLECULAR WEIGHT        : 296.44
WISWESSER LINE NOTATION : T8NTJ A2MYZUM &S-O4
COMPOUND DESCRIPTOR     : Drug
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Guanethidine monosulfate
   * N-(2-Guanidino ethyl)heptamethylenimine sulfate
   * (2-(Hexahydro-1(2H)-azocinyl)ethyl) guanidine hydrogen sulfate
   * 2-(Octahydro-1-azocinyl)ethyl guanidine sulphate
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Human
DOSE/DURATION           : 420 mg/6W (Intermittent)
REACTION SEVERITY       : Mild
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   4,592,1967
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 321,57,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   111,353,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   111,353,1972
 
                            *** END OF RECORD ***