*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF3240000
CHEMICAL NAME           : Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-,
                          sulfate (2:1)
CAS REGISTRY NUMBER     : 60-02-6
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C20-H44-N8.H2-O4-S
MOLECULAR WEIGHT        : 494.80
WISWESSER LINE NOTATION : T8NTJ A2MYZUM & 2WSQQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * beta-1-Azacyclooctylethylguanidine sulfate
   * Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1)
   * Guanethidine bisulfate
   * Guanethidine sulfate
   * Guanetidin sulfate
   * Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate
   * Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, sulfate (2:1)
   * (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate
   * Ismelin sulfate
   * Isobarin
   * NSC-29863
   * Octadin
   * Octadine
   * (2-(Octahydro-1-azocinyl)ethyl)guanidine sulfate
   * Octatensin
   * Oktadin
   * Sanotensin
   * SU-5864
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,22,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,22,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   URXXAF U.S.S.R. Patent Document.  (Gosudarstvennyi Komitet SSSR po Delam
   Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
   Volume(issue)/page/year: #0822829
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   URXXAF U.S.S.R. Patent Document.  (Gosudarstvennyi Komitet SSSR po Delam
   Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
   Volume(issue)/page/year: #0822829
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 278 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   URXXAF U.S.S.R. Patent Document.  (Gosudarstvennyi Komitet SSSR po Delam
   Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
   Volume(issue)/page/year: #0822829
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#08547
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3680 mg/kg/92D-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - structural change in nerve or sheath
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   41,209,1977
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE                    : 391 mg/kg
SEX/DURATION            : male 78 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JSXRAJ Journal of Sex Research.  (Soc. for the Scientific Study of Sex,
   Inc., Mt. Royal & Guilford Aves., Baltimore, MD 21202)  V.1-    1965-
   Volume(issue)/page/year: 3,69,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : male 56 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   BJPCBM British Journal of Pharmacology.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.34-    1968-  Volume(issue)/page/year:
   48,30,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 56,715,1979

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X6127
       No. of Facilities: 89 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 2323 (estimated)
       No. of Female Employees: 1200 (estimated)

 
                            *** END OF RECORD ***