*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : MF3240000 CHEMICAL NAME : Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (2:1) CAS REGISTRY NUMBER : 60-02-6 LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C20-H44-N8.H2-O4-S MOLECULAR WEIGHT : 494.80 WISWESSER LINE NOTATION : T8NTJ A2MYZUM & 2WSQQ COMPOUND DESCRIPTOR : Drug Reproductive Effector Human SYNONYMS/TRADE NAMES : * beta-1-Azacyclooctylethylguanidine sulfate * Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1) * Guanethidine bisulfate * Guanethidine sulfate * Guanetidin sulfate * Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate * Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, sulfate (2:1) * (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate * Ismelin sulfate * Isobarin * NSC-29863 * Octadin * Octadine * (2-(Octahydro-1-azocinyl)ethyl)guanidine sulfate * Octatensin * Oktadin * Sanotensin * SU-5864 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,22,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,22,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia). Volume(issue)/page/year: #0822829 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia). Volume(issue)/page/year: #0822829 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 278 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia). Volume(issue)/page/year: #0822829 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08547 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3680 mg/kg/92D-I TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 41,209,1977 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE : 391 mg/kg SEX/DURATION : male 78 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : JSXRAJ Journal of Sex Research. (Soc. for the Scientific Study of Sex, Inc., Mt. Royal & Guilford Aves., Baltimore, MD 21202) V.1- 1965- Volume(issue)/page/year: 3,69,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 1400 mg/kg SEX/DURATION : male 56 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 48,30,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE : 900 mg/kg SEX/DURATION : female 14 day(s) pre-mating female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 56,715,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6127 No. of Facilities: 89 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2323 (estimated) No. of Female Employees: 1200 (estimated) *** END OF RECORD ***