*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF3855000
CHEMICAL NAME           : Guanidine,
                          1,1'-((methylethanediylidene)dinitrilo)bis-,
                          dihydrochloride, dihydrate
CAS REGISTRY NUMBER     : 31959-87-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Tumorigen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 1,1'-(Methylethanedilidenedinitrilo)biguanidine dihydrochloride dihydrate
   * Methyl GAG
   * NSC 32946
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Rinsed with water
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 mg/24H
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 14,117,1979
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 pph/24H
REACTION SEVERITY       : Mild
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB269-596
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3900 mg/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   41,985,1968
 
                            *** END OF RECORD ***