*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF8775350
CHEMICAL NAME           : Guanosine,
                          2'-deoxy-P-thioadenylyl-(5'-3')-2'-deoxy-P-thiocytidy
                          lyl-(5'-3')-P-thiothy midylyl-
                          (5'-3')-P-thiothymidylyl-(5'-3')-P-thiothymidylyl(5'-
                          3')-2'-deoxy-P-thiogu anylyl-(5'-3')-
                          2'-deoxy-P-thioadenylyl-(5'-3')-2'-deoxy-P-thioguanyl
                          yl-(5'-3')-P-thiothym idylyl-(5'-3')-2'-
                          deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thioguanylyl-
                          (5'-3')-P-thiothymidy lyl-(5'-3')-2'-
                          deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thioguanylyl
                          -(5'-3')-2'-deoxy-P-t hiocytidylyl-
                          (5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytid
                          ylyl-(5'-3')-P-thioth ymidylyl-
                          (5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-
CAS REGISTRY NUMBER     : 151879-73-1
LAST UPDATED            : 199801
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Deoxyribonucleic acid, d(P-thio)(A-C-T-T-T-G-A-G-T-G-G-T-C-G-C-T-C-T-T-G)
   * ISIS 3521
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 320 mg/kg/8D-I
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 30,112,1996
 
                            *** END OF RECORD ***