*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF9290000
CHEMICAL NAME           : 5'-Guanylic acid, disodium salt
CAS REGISTRY NUMBER     : 5550-12-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C10-H12-N5-O8-P.2Na
MOLECULAR WEIGHT        : 407.22
WISWESSER LINE NOTATION : T56 BN DN FN HNVJ GZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA-
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Disodium GMP
   * Disodium 5'-gmp
   * Disodium 5'-guanylate
   * GMP disodium salt
   * 5'-Gmp disodium salt
   * GMP sodium salt
   * Guanylic acid sodium salt
   * Sodium GMP
   * Sodium guanosine 5'-monophosphate
   * Sodium guanylate
   * Sodium 5'-guanylate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >17300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3880 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2720 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5010 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5050 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3580 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AJINO* Ajinomoto Co., Inc.  (9 W. 57th St., Suite 4625, New York, NY 10019)
   Volume(issue)/page/year: -,-,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 gm/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,623,1984

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1092
       No. of Facilities: 177 (estimated)
       No. of Industries: 3
       No. of Occupations: 4
       No. of Employees: 1410 (estimated)
       No. of Female Employees: 33 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***