*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MI5230000
CHEMICAL NAME           : 1,6-Heptadiene-3,5-dione,
                          1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS REGISTRY NUMBER     : 458-37-7
OTHER CAS REGISTRY NOS. : 33171-04-9
BEILSTEIN REFERENCE NO. : 2306965
REFERENCE               : 4-08-00-03697 (Beilstein Handbook Reference)
LAST UPDATED            : 199801
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C21-H20-O6
MOLECULAR WEIGHT        : 368.41
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * C.I. 75300
   * C.I. Natural Yellow 3
   * Curcuma
   * Curcumin
   * Diferuloylmethane
   * E 100
   * Golden seal
   * Haidr
   * Halad
   * Haldar
   * Halud
   * Hydrastis
   * Indian saffron
   * Indian turmeric
   * Kacha haldi
   * Kurkumin
   * Merita earth
   * NCI-C61325
   * Orange Root
   * Souchet
   * Turmeric Yellow
   * Yellow ginger
   * Yellow puccoon
   * Yellow root
   * Yo-kin
   * Zlut prirodni 3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 25,447,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 64,601,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 73600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 18,83,1997
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 18,83,1997
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 36800 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Bone marrow
DOSE/DURATION           : 7980 mg/kg/38W (Continuous)
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 62,111,1990
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - mouse Bone marrow
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 62,111,1990
 
TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 73600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X4425
       No. of Facilities: 145 (estimated)
       No. of Industries: 3
       No. of Occupations: 3
       No. of Employees: 690 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***