*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MI5242000
CHEMICAL NAME           : 2,5-Heptadienoic acid,
                          7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-
                          dihydroxycyclopentyl)-, methyl ester,
                          (1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))-
CAS REGISTRY NUMBER     : 62524-99-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C23-H29-Cl-O6
MOLECULAR WEIGHT        : 436.97
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 16-(3-Chlorophenoxy)-17,18,19,20-tetranor-2,3-trans-didehydro-pgf2-alpha  
   methyl ester
   * Delprostenate
   * ONO 1052
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 39 ug/kg
SEX/DURATION            : female 3-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,525,1980
 
                            *** END OF RECORD ***