*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MI7601180
CHEMICAL NAME           : Heptanamide,
                          7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)
                          amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-,
                          trihydrochloride, dihydrate
CAS REGISTRY NUMBER     : 85468-01-5
LAST UPDATED            : 199206
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H37-N7-O3.3Cl-H.2H2-O
MOLECULAR WEIGHT        : 531.01
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazononadecane-10,13-dione  
   trihydrochloride 2H2O
   * (-)-15-Deoxyspergualine trihydrochloride dihydrate
   * NKT-01 trihydrochloride dihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 35,1665,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 35,1665,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 61 mg/kg/13W-C
TOXIC EFFECTS :
   Endocrine - other changes
   Endocrine - changes in thymus weight
   Blood - normocytic anemia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 25,927,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 27300 ug/kg/13W-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 25,2954,1991
 
                            *** END OF RECORD ***