*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MI7601200
CHEMICAL NAME           : Heptanamide,
                          7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)
                          amino)butyl)amino)-1- hydroxy-2-oxoethyl)-,
                          trihydrochloride, dihydrate, (-)-
CAS REGISTRY NUMBER     : 84937-45-1
LAST UPDATED            : 199312
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H37-N7-O3.3Cl-H.2H2-O
MOLECULAR WEIGHT        : 531.01
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   (-)-(15S)-1-Amino-19-guanidino-11,15-dihydroxy-4,9,12-triazanonadecane-1
     0,13-dione 3HCl
   * (-)-15-Deoxyspergualin
   * (-)-15-Deoxyspergualin trihydrochloride dihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 35,1665,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 35,1665,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg/13W-I
TOXIC EFFECTS :
   Blood - changes in erythrocyte (RBC) count
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 14,237,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 mg/kg/13W-I
TOXIC EFFECTS :
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in spleen
   Related to Chronic Data - death
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 14,247,1989
 
                            *** END OF RECORD ***