*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MI9750000
CHEMICAL NAME : Heptanedioic acid,
mono(2-(4-((2,6-dideoxy-2-fluoro-alpha-L-talopyranosy
l)oxy)-1,2,3,4,6,11-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na
phthacenyl)-2-oxoethy l) ester, (2S-cis)-
CAS REGISTRY NUMBER : 116521-53-0
LAST UPDATED : 199403
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C34-H37-F-O15
MOLECULAR WEIGHT : 704.71
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycinone-14-O-hemip
imelate
* 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)pimelyladriamycinone
* FAD-104
* FT-Adm
* ME2303
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 179 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Behavioral - muscle weakness
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience
Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
Volume(issue)/page/year: 14,435,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 72800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
14,756,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 138 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Behavioral - muscle weakness
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience
Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
Volume(issue)/page/year: 14,435,1988
*** END OF RECORD ***