*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MJ5990000
CHEMICAL NAME           : 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, L-
CAS REGISTRY NUMBER     : 125-58-6
BEILSTEIN REFERENCE NO. : 3213668
REFERENCE               : 3-14-00-00278 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H27-N-O
MOLECULAR WEIGHT        : 309.49
WISWESSER LINE NOTATION : 2VXR&R&1Y1&N1&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
   * (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
   * 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-
   * Levomethadone
   * Levothyl
   * (-)-Methadone
   * l-Methadone
   * (6R)-Methadone
   * Polamivet
   * l-Polamivet
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 97 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 110,135,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 9,280,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEXPAG Medicina Experimentalis.  (Basel, Switzerland)  V.1-11, 1959-64;
   V.18-19, 1968-69.  For publisher information, see JNMDBO.
   Volume(issue)/page/year: 2,323,1960
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 198,340,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Testis
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   27,123,1978
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Testis
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   27,123,1978
 
                            *** END OF RECORD ***